Control and regulation of acetate overflow in Escherichia coli

نویسندگان

چکیده

Overflow metabolism refers to the production of seemingly wasteful by-products by cells during growth on glucose even when oxygen is abundant. Two theories have been proposed explain acetate overflow in Escherichia coli – global control central and local pathway but neither accounts for all observations. Here, we develop a kinetic model E. that quantitatively observed behaviours successfully predicts response new perturbations. We reconcile these clarify origin, control, regulation flux. also find that, turns, regulates coordinating expression glycolytic TCA genes. Acetate should not be considered end-product since it co-substrate regulator . This has broad implications our understanding metabolism.

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ژورنال

عنوان ژورنال: eLife

سال: 2021

ISSN: ['2050-084X']

DOI: https://doi.org/10.7554/elife.63661